TRANSLATIONAL PHYSIOLOGY Phasic hemodynamics and reverse blood flows in the aortic isthmus and pulmonary arteries of preterm lambs with pulmonary vascular dysfunction
نویسندگان
چکیده
Pierre-Henri Rolland, Pascal de Lagausie, Euletheris Stathopoulos, Olivier Leprètre, Gilles Viudes, Guillaume Gorincour, Géraldine Hery, Catherine de Magnée, Olivier Paut, and Jean-Michel Guys Physiopathology and Vascular Therapeutics, School of Medicine, University of the Mediterranean Sea, Marseilles; Departments of Pediatric Surgery Department, Pediatric Reanimation, and Pediatric Radiology, LaTimone-Hospital, Marseilles; and National Institute for Agronomic Research, Montpellier, France
منابع مشابه
Phasic hemodynamics and reverse blood flows in the aortic isthmus and pulmonary arteries of preterm lambs with pulmonary vascular dysfunction.
Time-domain representations of the fetal aortopulmonary circulation were carried out in lamb fetuses to study hemodynamic consequences of congenital diaphragmatic hernia (CDH) and the effects of endothelin-receptor antagonist tezosentan (3 mg/45 min). From the isthmic aortic and left pulmonary artery (PA) flows (Q) and isthmic aortic, PA, and left auricle pressures (P) on day 135 in 10 controls...
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Experimentally, a typical ∼2-min cord clamp-to-ventilation interval in preterm lambs is accompanied by increased hemodynamic lability of the birth transition. However, whether this lability is related to development of asphyxia after cord clamping, or can be avoided with a shorter clamp-to-ventilation interval, is unknown. To address these questions, anesthetized preterm fetal lambs (gestation ...
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Background. This study investigated the effects of impairment to placental flow on flow patterns through the aortic isthmus because in the fetus, this vascular segment is the link between the parallel vascular systems perfused by the left and right ventricles. Methods and Results. A progressive increase in resistance to blood flow through the placenta was created in seven exteriorized fetal lam...
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